Core Facilities & CAS Institutes
CAS research often relies on the use of shared instrumentation for routine and advanced analyses. CAS Core Facilities are designed to help researchers improve the health and wellbeing of people, create healthy and sustainable communities, and explore ways to advance healthy communities through the novel and innovative research.
The Electron Microscope Core Facility provides microscope services to universities, industry, and commercial labs to include Transmission and Scanning Electron Microscopy, Transmitted and Fluorescent Light Microscopy, Specimen Preparation, and Instrument Training in TEM, SEM, Light Microscopy, and Consulting.
The USF NMR Core Facility houses a range of nuclear magnetic resonance instrumentation, including one of Florida's highest field strength NMRs (800 MHz), Expertise and facilities are available for academic, government, and commercial structural studies, metabolomics, and materials research. specializes in measuring the magnetic properties of atomic nuclei, which make up the molecules that can become the drugs of the future.
The CMMB Core offers a wide range of resources to include products, education, services and support that assist scientists, industry, and students in solving research problems.
The Chemical Purification, Analysis and Screening Core Facility offers its expertise in small-molecules natural product chemistry with chromatographic separation and purification (MPLC, LC/MS SQ, HPLC, UHPLC), mass spectrometry (LC-MS SQ, LC-MS QqQ, LC-MS QToF, GC-MSD and GC-MS QToF) and ADME screening (PAMPA and drug solubility).
The services also include general spectroscopic characterization (UV, FTIR), lyophilization (benchtop and general purpose freeze-dryer), synthesis (microwave reactor), microbiology (biosafety cabinets) and high-throughput screening development capability (liquid handling robot and multimode microplate reader). The facility provides research lab training and assistance to the university, the public, and private institutions.
The CGA Core Facility specializes in low-level trace element analysis. The core employs inductively coupled plasma (ICP) spectrometers with coupled laser and HPLC to provide analyses on water, soils, chemicals, biologic material, and rock to the greater USF community, national and global research institutions as well as to federal and local government agencies. Core specializes in the determination of trace metals in a variety of materials including water samples, environmental samples (e.g., soil, sludge) and most rock types. The lab provides analysis to the public, research institutions, government agencies, and universities.
The Stable Isotope Lab offers analyses of both organic and inorganic samples (including C, H, O, N and S elements) to researchers from geology, anthropology, biology, geography and more.
The CAS Proteomics Core provides expertise in biological mass spectrometry as it relates to project development, experimental design, sample processing, and data analysis for proteomics studies. The core facility also provides training in sample processing and database searching for graduate students and post-doctoral scholars.
The core maintains a hybrid quadrupole-orbitrap mass spectrometer (Q Exactive Plus, Thermo Scientific) equipped with a Thermo Ultimate 3000 UHPLC system. The Q Executive Plus is ideal for proteomics applications such as large-scale protein identification experiments from complex biological samples, including relative quantitation as well as routine protein identification from immunoprecipitation experiments and various post-translational modification (PTM) analyses. The Proteomics Core is proficient in a number of sample processing workflows and has broad experience with a variety of sample types. Comprehensive data analysis is provided, primarily relying on MaxQuant and Perseus software packages. The bioinformatic analysis is also available using software Ingenuity Pathway Analysis (IPA).