Genome Integrity & Mechanisms of Aging
Research within the Genome Integrity & Mechanisms of Aging (GIMA) group aims to enhance our understanding of fundamental, molecular and cellular mechanisms associated with aging and aging-related diseases. The wide range of areas of interest includes genomic instability and DNA repair, mitochondrial dysfunction, cellular stress response, dysregulation of gene expression in cancer, and diabetes. Experimental applications within our interdisciplinary focus group include a broad array of model systems, including transgenic and knockout mice, mammalian cell culture, the budding yeast Saccharomyces cerevisiae, the nematode worm C. elegans and the fruitfly Drosophila melanogaster. Collaborations with our focus group are found with the H. Lee Moffitt Cancer Center, the USF Pedriatric Epidemiology Center, USF College of Medicine, USF Departments of Chemistry, Physics, and Electrical Engineering, the Byrd Alzheimer's Institute and the USF Center for Drug Discovery and Innovation, as well as research groups at other universities.