Hope For The Hearing-Impaired
The first-ever medication to treat age-related hearing loss could potentially receive FDA approval through a comprehensive study being conducted at USF.
Robert Frisina, chair of the USF medical engineering department and director of the USF Global Center for Hearing and Speech Research, and his team were awarded a U.S. patent for his theory that you can slow hearing loss by combining supplements for the hormone aldosterone with anti-inflammatory medications, such as aspirin or ibuprofen. Aldosterone is a naturally occurring steroid that influences sodium and potassium regulation in the body, including the inner ear used for hearing. Its level typically decreases as we age, impacting auditory perception.
“Our novel idea, embodied in the new patent, involves boosting aldosterone to young adult levels, to make the ear ‘young’ again,” Frisina says.
The research is part of a five-year, $9 million grant awarded by the National Institutes of Health to USF’s Global Center. Since its renewal launch in 2016, the study has included pre-clinical trials on mice. The aging mice received subcutaneous, time release aldosterone treatments for four months, equivalent to about seven-eight years of treatment for people.
Frisina and his colleagues found untreated aging mice experienced a 50 percent decline
in aldosterone compared to young adult mice. However, following treatment, the levels
rose to a near normal range. It’s important to note that the hormone supplement did
not induce potential negative side effects, such as elevating blood pressure. Most
importantly, the treated mice did not undergo age-related hearing loss during the
study, whereas the control mice did suffer from continued age-linked hearing impairment.
Frisina’s team is now in the process of licensing the patent and if successful, will then conduct four levels of FDA human clinical trials in collaboration with the pharmaceutical company doing the licensing. Once the drug is FDA-approved, it would then be available to the public. Its eventual commercialization could be life-changing for many, as age-related hearing loss is the No. 1 communication disorder of the elderly population, and impacts more people than any other neurodegenerative disease of aging.
– Tina Meketa, USF News