The USF Center for Entrepreneurship is a nationally ranked, campus-wide, interdisciplinary center located in the Muma College of Business. Since its founding in 2002, It has developed as a partnership with the Muma College of Business, USF Health, the College of Arts and Science, the College of Engineering, and the Patel College for Global Sustainability. It operates, in partnership with USF CONNECT, the USF Student Innovation Incubator founded in 2013. The center provides professional connections for students with the Tampa Bay business community.

The center 's academic entrepreneurship programs have been recognized as nationally preeminent since 2007 as one of the top 25 graduate entrepreneurship programs in the nation.

The Center hosts annually a variety of student competitions including the Frank and Ellen Daveler Entrepreneurship Program, the USF Business Plan Competition and the Florida Blue Health Innovation Challenge. It provides both in-classroom and extracurricular training programs, as well as research opportunities for students and faculty. The center partners with other USF programs and the business community to promote the development of critical skills necessary to identify business opportunities and transform those ideas into successful endeavors using innovation, creativity, and entrepreneurship.