Pan Lab

Membrane Biophysics

Research interests

  • Peptidomimetics (peptide mimics) interacting with bacterial membranes
  • Protein aggregates (e.g., oligomers and fibrils) interacting with lipid membranes
  • Phase separation in model lipid bilayers
  • Amphipathic peptides modulate lipid membrane curvature and structure 

Research examples
Experimental Images Description
AFM phase Phase separation of lipid bilayers revealed by atomic force microscopy.
GUV phase Giant unilamellar vesicles (GUVs) acting as a platform for observing phase separation. The two images below were obtained using fluorescence microscopy.
Aspiration Micropipette aspiration of giant unilamellar vesicles. This technique is useful to reveal kinetic impacts of active molecules on vesicle morphology and integrity.
Aggregates AFM images of different forms of amyloid aggregates.
bacteria Imaging bacterial morphology using atomic force microscopy.

 Research Support

NIH R15, Award number: 1R15GM117531-01 (12/01/2015 – 11/30/2019)

Title: Characterizing Interactions between Bacterial Membranes and Peptidomimetics for the Development of Antibiotics Targeting Multidrug Resistant Bacteria.