Biomolecule Transformations and Analysis
Design, synthesis and investigation of bioactive peptidomimetics; development of novel biomaterials; development of novel molecular probes and drug candidates; protein and nucleic acid surface recognition and modulation of protein-protein interactions.
Our laboratory is actively engaged in the organic synthesis of peptide mimics, natural products, and their congeners. These compounds are used to probe molecular recognition events and to target disease-relevant pathways. We are particularly fascinated by the impact of structurally complex amino acids on conformation and bioactivity.
Research in the Evans-Nguyen lab interfaces chemical analysis and engineering principles to explore various aspects of mass spectrometry instrumentation. Chemical targets span the fields of defense, space, and the clinical lab.
Dr. Li's research activities are focused on supramolecular chemistry based on coordination-driven self-assembly. His research group is centered on the design, synthesis and self-assembly of giant metallo-supramolecules with increasing complexity and diversity for the development of functional materials with high-performance.
Dr. Malik's research activities are focused on separations chemistry. His research group is engaged in developing advanced technology for high-performance differential migration micro separation techniques in analytical chemistry.