Drug Discovery and Medicinal Chemistry
Design, synthesis and investigation of bioactive peptidomimetics; development of novel biomaterials; development of novel molecular probes and drug candidates; protein and nucleic acid surface recognition and modulation of protein-protein interactions.
Our laboratory is actively engaged in the organic synthesis of peptide mimics, natural products, and their congeners. These compounds are used to probe molecular recognition events and to target disease-relevant pathways. We are particularly fascinated by the impact of structurally complex amino acids on conformation and bioactivity.
Dr. Li's research activities are focused on supramolecular chemistry based on coordination-driven self-assembly. His research group is centered on the design, synthesis and self-assembly of giant metallo-supramolecules with increasing complexity and diversity for the development of functional materials with high-performance.
Our research program is grounded in synthetic organic chemistry with a specific focus on the development of new reactions, the design of new reagents, and the total synthesis of natural products with anti-cancer activity. In collaboration with other research groups at Moffitt, we will apply our chemistry to synthesize chemical probes designed to interrogate the function of key oncoproteins and immune-regulatory proteins, while ultimately seeking to develop these probes and lead compounds into novel anti-cancer drugs.Lee Woodcock