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Robert Frisina

Distinguished University Professor and Department Chair
Office: ENC 3504 | Email | 813-974-4394

EDUCATION
Ph.D. in Bioengineering, Physioloy, Neuroscience, Syracuse University, New York (1983)
Bachelors in Experimental Psychology and Economics, Hamilton College, New York (1977)

RESEARCH AREAS
Development of Bio-therapeutic Systems, Devices and Compounds for Treating Sensory Deficits; Emphasis on Bench-to-Bedside Investigations of the Auditory System, and Translational Research on Deafness and Other Neuroengineering Applications.

MEMBERSHIPS
1977 - Phi Beta Kappa
1977 - Sigma Xi; Psi Chi
1979 - Fellow, Acoustical Society of America - ASA
1979 - International Brain Research Organization - IBRO
1979 - Society for Neuroscience - SFN
1982 - Association for Research in Otolaryngology - ARO
1985-2010 - Charter Member, Society for Neuroscience, Rochester Chapter
1990-2009 - Scientific Fellow, American Academy Otolaryngology-Head & Neck Surgery
1991-2009 - American Speech, Language, Hearing Association - ASHA
2011- National Academy of Inventors - NAI
2012 - Member, IEEE
2013 - Biomedical Engineering Society – BMES
2013 - American Association for the Advancement of Science - AAAS
2016 - Fellow, American Institute for Medical and Biological Engineering – AIMBE
2017 - Fellow, Biomedical Engineering Society - BMES
2018 - Senior Member – IEEE
2019 - Senior Member, National Academy of Inventors - NAI
2019 - Fellow, American Association for the Advancement of Science - AAAS

RECENT COURSES TAUGHT
Guest Lecturer for Professional Seminar Series, Industrial & Management Systems Engineering Dept.- College of Engineering, Univ. of South Florida (1/19 to present)

Guest Lecturer for EML 4930/6930, Biomedical Devices & Materials, Mechanical Engineering Dept.- College of Engineering, Univ. of South Florida (8/16 to present)

Research Lecturer for Otolaryngology Department Surgical Resident Academic Seminar Series- University of South Florida Medical School (8/15 to present)

Course Director/Instructor for BME 4100/5105, Medical Engineering, Dept., Chemical & Biomedical Engineering- College of Engineering, Univ. of South Florida (1/11 to present)

RESEARCH GRANTS

CURRENT
Granting Agency: NIH-National Institute on Aging (NIA):
Project Title: "Aging Auditory System: Presbycusis & its Neural Bases"
NIH Impact Priority Score=10, Percentile=1%;   Grant #: P01 AG009524-23
P.I., Project Leader and Core Director: Robert Frisina, Ph.D.
P.L. and C.D.: Joseph Walton, Ph.D.
P.L.: David Eddins, Ph.D.
Total Costs for Years 21-25: $9,100,000.
Start Date: 3-15-16; Duration: 5 years.
Aims: Determine and characterize the neural and molecular bases of age-related hearing loss in humans and animal models to move towards better technological and biotherapeutic       translational research interventions.

Granting Agency: NIH-Nat. Inst. on Deafness & Communication Disorders (NIDCD)
Project Title: “Enabling Microsystem Technologies for Advanced Drug Delivery”
NIH Impact Priority Score=14, Percentile=1%; Grant #: R01 DC014568-04
MPI: Robert Frisina, Ph.D.
MPI: David Borkholder, Ph.D.
Co-I: Joseph Walton, Ph.D.
Total Costs: $3,000,000.
Start and End Dates: 4/01/15 – 3/31/20
Aims: Develop novel microsystems and programmable micropumps for local drug delivery to targeted organ systems, starting with drug delivery to the inner ear to prevent or treat hearing loss, deafness and balance problems.

Granting Agency: NIH/NIDCD
Project Title: “Elucidation of Under-Investigated Biological Mechanisms of Age-Related Hearing Loss”
Grant #: R21 DC017039-01 , NIH Percentile Score: 4%
PI: Robert Frisina, Ph.D.
Dates: 3/01/19 – 2/28/21
Total Costs (USF): $412,500
Aims: Investigate autophagy pathways in the inner ear to prevent or treat acquired hearing loss, focusing upon age-related hearing loss.

Granting Agency: NIH - Nat. Inst. on Aging (NIA) and Nat. Inst. on Deafness & Communication Disorders (NIDCD)
Project Title: “Aging and Speech Communication Conference”
Grant #: R13 AG064977-01
PI: Robert Frisina, Ph.D.
Total Costs: $28,000
Start and End Dates: 9/01/19 – 8/31/20
Aims: Help support an international conference on age-related hearing loss and speech communication in the elderly.

Granting Agency: England- Action on Hearing Loss-Royal National Inst. for the Deaf
Project Title: “mGlu7 Allosteric Modulators for the Treatment of Hearing Loss”
USF PI: Robert Frisina, Ph.D.
USF Co-I: Joseph Walton, Ph.D.
Start and End Dates: 6/01/16 – 8/31/19
Total Costs (USF): $212,000.
Aims: Develop and test new drugs to modulate the synaptic mechanisms of glutamate transmission in the auditory system to prevent or treat hearing loss and tinnitus due to noise-overexposure and aging. Website

PENDING
Granting Agency: NIH-Nat. Inst. on Deafness & Communication Disorders (NIDCD)
Project Title: “Enabling Microsystem Technologies for Advanced Drug Delivery”
Grant #: R01 DC014568-06, NIH Priority Score% = 20%
MPI: Robert Frisina, Ph.D.
MPI: David Borkholder, Ph.D.
Co-I: Joseph Walton, Ph.D.
Total Costs: $3,500,000.
Start and End Dates: 4/01/20 – 3/31/25
Aims: Develop novel microsystems and programmable micropumps for local drug delivery to targeted organ systems, starting with drug delivery to the inner ear via cochlear implants to prevent or treat deafness.

PREVIOUS
Granting Agency: NIH-National Institute on Aging (NIA):
Project Title: "Aging Auditory System: Presbycusis & its Neural Bases"
NIH Impact Priority Score=22, Percentile=9%;   Grant #: P01 AG009524-20
Includes NIH Diversity Supplements, BME PhD Students
P.I. and Core Director (C.D.): Robert Frisina, Ph.D.
P.D. and C.D.: Joseph Walton, Ph.D.
P.D.: David Eddins, Ph.D.
Total Costs for Years 16-20: $4,300,000.
Start Date: 9-15-10; Duration: 5 years.
Aims: Determine and characterize the neural and molecular bases of age-related hearing loss in humans and animal models to move towards better technological and biotherapeutic       translational research interventions.

Granting Agency: NIH - Nat. Inst. on Aging (NIA) and Nat. Inst. on Deafness & Communication Disorders (NIDCD)
Project Title: “Aging and Speech Communication Conference”
NIH Impact Priority Score=14, Percentile=1%; Grant #: R13 AG057190-01
PI: Robert Frisina, Ph.D.
Total Costs: $40,000.
Start and End Dates: 7/01/17 – 6/30/18
Aims: Help support an international conference on age-related hearing loss and speech communication in the elderly.

Granting Agency: NIH-National Cancer Institute (NCI):
Project Title: "Genetic Susceptibility and Biomarkers of Platinum-Related Toxicities”
Grant #: R01 CA157823-05
P.I.: Lois Travis, M.D./Ph.D., Univ. Rochester Medical School
Co-Investigator: Robert Frisina, Ph.D.
Start Date: 9-25-12; Duration: 5 years.
Aims: Determine relations between platinum-induced hearing loss, neuropathy and genetics for testicular cancer survivors.

Granting Agency: Autifony Therapeutics
Project Title: “A Balanced, Randomized, Placebo-Controlled, Double-Blind Study of the
Efficacy and Safety of AUT00063 Versus Placebo in Age-Related Hearing
Loss [CLARITY-1 Study]”
PI: Robert Frisina, Ph.D.
Co-Investigator, Terry Chisolm, Ph.D.
Co-Investigator, Paul Boyev, M.D.
Co-Investigator, Victoria Sanchez-Williams, Ph.D., Au.D.
Total Costs: $403,000.
Dates: December 15, 2014 to December 31, 2016
Aims: Conduct FDA Phase 2 Clinical Trials on a new drug that modulates Kv3.1 voltage-gated potassium channels in the central auditory system.

Granting Agency: NIH-National Institute on Aging (NIA): Project Title: "Aging Auditory System: Presbycusis & its Neural Bases"
Grant #: P01 AG09524-15
P.I.: D. Robert Frisina, Ph.D. – NTID, Rochester Institute of Technology, Effort: 65%
Co-Director and P.D.: Robert D. Frisina, Ph.D., Effort: 55%
C.D.: William O'Neill, Ph.D., Effort: 10%
P.D.: James Ison, Ph.D., Effort: 50%
P.D.: Joseph Walton, Ph.D., Effort: 65%
Total Costs: $13,500,000.
Inclusive Dates: 6-1-91 to 4-30-10
Aims: Determine and characterize the neural and molecular bases of age-related hearing loss in humans and animal models.

Granting Agency: NIH – Inter-Institute Toolbox Initiative – Auditory Sub-domain
Project Title: “Auditory Sub-domain Development and Validation Phase”
PI: Robert Frisina, Ph.D., Effort: 10%
Co-I: Joseph Walton, Ph.D.
Co-I: David Eddins, Ph.D.
Start and End Dates: 10/05/11 – 6/30/12
Total Costs: $143,000
Aims: Test and validate the applicability and feasibility of automated hearing threshold measurements relative to standard audiometric methodologies, for large-scale epidemiological studies.

Granting Agency: NIH-National Institute on Deafness & Communication Disorders (NIDCD) – K25 Grant
Project Title: “Improved Micro-Technologies for Inner Ear Drug Delivery”
PI: Dr. David Borkholder – College of Engineering, Rochester Institute of Technology
Mentor: Dr. Robert D. Frisina
Start and End Dates: 7/01/06 – 6/30/11
Total Costs: $902,583.
Aims: The Specific Aims of this grant focus on developing micropumps for inner ear drug delivery for cochlear protection from ototoxic insults, and delaying or preventing age-related hearing loss – presbycusis.

Granting Agency: NIH - National Institute on Aging (NIA) - K01 Grant
Project Title: “The Genetics of Age-Related Hearing Loss”
PI: Dr. Dina Newman – College of Science, Rochester Institute of Technology
Mentor: Dr. Robert Frisina
Start and End Dates: 8/01/06 – 6/30/11
Total Costs: $450,000.
Aims: The Specific Aims of this grant focus on identifying human genes that may be related to, or predispose one to, age-related hearing loss – presbycusis.

Granting Agency: NIH – Inter-Institute Toolbox Initiative – Auditory Sub-domain
Project Title: “Auditory Sub-domain Development and Validation Phase”
PI: Robert Frisina, Ph.D., Effort: 7%
Co-I: Joseph Walton, Ph.D., Effort: 50%
Co-I: David Eddins, Ph.D., Effort: 50%
Start and End Dates: 4/01/10 – 7/31/10
Total Costs: $99,459
Aims: Develop and validate the applicability and feasibility of automated hearing threshold measurements relative to standard audiometric methodologies, for large-scale epidemiological studies.

Granting Agency: NIH – National Institute on Deafness & Comm. Disorders (NIDCD)
Project Title: “Hearing Impairment in HIV/AIDS”
Grant#: R01 DC009395-01
PI: Amneris Luque, M.D. – U. Rochester Medical School
Co-PI: Robert Frisina, Ph.D.
Start and End Dates: 7/01/09 – 6/30/14
Total Costs: $1,923,380
Aims: Characterize the nature and extent of hearing impairment in HIV/AIDS patients, including longitudinal changes with different treatment regimes, and possible sensory improvement with effective treatments.

Granting Agency: Blue Highway – Welch Allyn
Project Title: “Continuous Glucose Detection with Nano-scale Sensors”
PI: Dr. David Borkholder – College of Engineering, Rochester Institute of Technology
Co-PI: Dr. Robert D. Frisina
Start and End Dates: 9/01/09 – 6/30/10
Total Costs: $88,118.
Aims: The Specific Aims of this grant focus on developing new in vivo, rapid sub-cutaneous tests for blood glucose levels, with applications for diabetes and other metabolic disorders.

Granting Agency: NIH - National Institute on Deafness & Comm. Disorders (NIDCD)
Project Title: “Center for Navigation & Communication Sciences”
Core Center Grant#: P30 DC005409-06
PI: Dr. Gary Paige – U. Rochester Medical School
Core Leader: Dr. Robert Frisina, Effort: 5%
Co-Is: Drs. Joseph Walton and David Eddins
Start and End Dates: 7/01/08 – 6/30/13
Total Funding for 2nd 5 years: $2,000,000
Aims: This Core‑Center Grant allows investigators to efficiently share costly, time‑consuming, essential but cumbersome, and in many cases innovative research services, in the areas of human subject recruiting, scheduling and screening, and in other technical areas such as computer system and database development.

HONORS and AWARDS
Fellow – American Association for the Advancement of Science (AAAS), 2019-present.
Senior Member - National Academy of Inventors, University of South Florida, 2019-present.
IEEE Senior Member – 2018-present.
Fellow and Steering Committee Member - Florida Association for Nanobiotechnology
Distinguished University Professor – Univ. South Florida- Tampa, 2017-present; given each year to 3 of ~2000 faculty members.
Fellow – Biomedical Engineering Society (BMES), 2017-present.
Fellow – American Institute for Medical & Biological Engineering (AIMBE), 2015-present.
Sr. Researcher of the Year Award, College of Engineering, University of South Florida, 2014
National Academy of Inventors, University of South Florida, 2011- present.
Fellow - Acoustical Society of America (ASA), 1994-present.
Scientific Fellow - American Academy of Otolaryngology - Head & Neck Surgery, 1990-2009.
Intellectual Property Productivity Award, Tech. Licensing Office, Rochester Inst. Tech., 2007.
Distinguished Researcher in Biological Sciences, RIT, 2003-2007.
Silver Certificate, Acoustical Society of America, 2004.
Appointed to Technical Committee on Psychological & Physiological Acoustics by Executive Council of the Acoustical Society of Am., 1988-2004; Chair -Subcomm. for National Meetings, 1990-3.
National Institutes of Health FIRST Award in Communicative and Neurosensory Disorders, 1988-1994.
National Institutes of Health Fellow in Sensory Physiology and Biophysics, 1983-1986.
National Science Foundation Graduate Fellow in Physiology, 1978-1981.
Honorary Syracuse University Graduate Fellow, 1978-1981.
Syracuse University Graduate Fellowship, 1978-1979.
Root Fellow, 1977-1978, graduate award given by Hamilton College to 3 seniors who have "shown marked ability & special aptitude for research in the depts. of science". (Hamilton Catalog)
Syracuse University Graduate Scholar, 1977-1978.
Phi Beta Kappa, Sigma Xi, Psi Chi, 1977.
Summa Cum Laude A.B. Degree, 1977.
Departmental honors in Psychology and Economics, 1977.
Marder Prize, 1977, awarded to the senior who most excels in Psychology.
Certificate of Appreciation, Utica Volunteer Agency, 1977.
Bennet Scholar, 1976-77, honor bestowed upon the senior who completed their junior year with distinction.
In 1976, a faculty committee chaired by the Dean of Hamilton College nominated one senior for the Rhodes Scholarship and two seniors for the Marshall Scholarship.
Dean's List-High Honor, 1974-1977.
Gilbert Prize, 1974, presented for greatest scholastic improvement in the freshman year.
New York State Regents Scholar, 1973-1977.
Bronze Citizenship Medal, Sons of the American Revolution, 1973.

RECENT PUBLICATIONS
Note: *Asterisks indicate publications where Dr. Frisina’s trainee is an author (name italicized).

Kearns, S.L., Fung, C… R.D. Frisina…L.H. Einhorn, L.B. Travis, (2020- In Press) Association of Cisplatin-Related Adverse Health Outcomes with Disability and Unemployment Among Testicular Cancer Survivors. J. Nat. Cancer Inst. – Cancer Spectrum. [Impact Factor ~12]

Moudgalya, S.S., Zhu, X., Walton, J.P., Budzevich, M., Cahill, N.D., Frisina, R.D., Wilson, K., Borkholder, D. A. (2019) Cochlear Pharmacokinetics – Micro-Computed Tomography and Learning-Prediction Modeling for Transport Parameter Determination. Hearing Res. 380, 46-59. [Cover Article; Impact Factor ~3]

Forouzandeh, F.; Zhu, X.; Alfadhel, A.; Ding, B.; Walton, J.P.; Cormier, D.; Frisina, R.D.; Borkholder, D.A. (2019) A nanoliter resolution implantable micropump for murine inner ear drug delivery. J. Controlled Release. 298, 27-37. [Impact Factor ~8]

*Williamson, T.T., Ding, B., Zhu, X., Frisina, R.D. (2019) Hormone Replacement Therapy Attenuates Hearing Loss: Mechanisms Involving Estrogen and the IGF-1 Pathway. Aging Cell. 18:e12939; 1-15. https://doi.org/10.1111/acel.12939 [Impact Factor ~8]

*Dituri, J., Siddiqi, F., Frisina, R.D. (2019) Real-time heart rate variability analysis as a means of hypercapnia detection. Undersea & Hyperbaric Medicine. 46, 503-507. [H Index=38].

Ding, B., J.P. Walton, X. Zhu, R.D. Frisina. (2018) Age-related changes in Na, K-ATPase expression, subunit isoform selection and assembly in the stria vascularis lateral wall of mouse cochlea. Hearing Res. 367:59-73. [Impact Factor ~3]

Antoine, M.W., Zhu, X., Vijayakumar, S., Arezzo, J.C., McKeehan, N., Zukin, R.S., Borkholder, D., Jones, S., Frisina, R.D. Hébert, J.M. (2018) Early Uneven Ear Input Induces Long Lasting Differences in Left Right Motor Function. Plos Biology. 6(3): e2002988. https://doi.org/10.1371/journal.pbio.2002988 [Impact Factor ~10]

*Amanipour, R., Zhu, X., Duvey, G., Celanire, S., Walton, J.P. Frisina, R.D. Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice. (2018). IEEE Conf. Proc. Explore: Engineer. Med. Biol. Soc. 1210-1213.

*Watson, N., Ding, B., X. Zhu, R.D. Frisina. (2017) Chronic Inflammation - Inflammaging - in the Ageing Cochlea: A Novel Target for Future Presbycusis Therapy. Aging Research Rev., 40, 142-148. [Impact Factor ~9]

Wheeler, H.E., Gamazon, E.R., Frisina, R.D., Perez-Cervantes, C., El Charif, O., Mapes, B., Gruener, R.F., Wing, C., Fossa, S.D., Feldman, D.R., Hamilton, R.J., Vaughn, D.J., Beard, C.J., Fung, C., Einhorn, L.H., Kollmannsberger, C., Kim, J., Mushiroda, T., Kubo, K., Ardeshir-Rouhani-Fard, S., Cox, N.J., Dolan, M.E., Travis, L.B. (2017) Variants in WFS1 and other Mendelian deafness genes are associated with cisplatin-associated ototoxicity. Clinical Cancer Res. 23:3325-33. doi: 10.1158/1078-0432.CCR-16-2809. [Impact Factor ~10]

*Bazard, P., Frisina, R.D., Walton, J.P., Bhethanabotla, V. (2017- On Line) Nanoparticle-based Plasmonic Transduction for Modulation of Electrically Excitable Cells. Nature- Scientific Reports. [Impact Factor ~5]

Frisina^, R.D., H.E. Wheeler^, S.D. Fossa, S. Kerns, H.D. Sesso, D.R. Feldman, R. Hamilton, D.J. Vaughn, C.J. Beard, C. Fung, A. Budnick, A. Weinzerl, E. Johnson, L.H. Einhorn, N.J. Cox, M.E Dolan, L.B. Travis. (2016) Comprehensive Characterization of Cisplatin-Related Hearing Loss and Tinnitus: Implications for Improved Management and Therapeutics. J. Clinical Oncology. 34(23):2712-20, ^equal 1st authors. with Editorial. [Impact Factor ~26]

Editorial: Oldenburg J, Gietema JA. The Sound of Silence: A Proxy for Platinum Toxicity. J Clin Oncol 2016;34(23):2687-9.

Frisina^, R.D., Ding^, B., X. Zhu, J.P. Walton. (2016– On Line) Age-Related Hearing Loss: Prevention of Threshold Declines, Cell Loss and Apoptosis in Spiral Ganglion Neurons. Aging. ^equal 1st authors. [Impact Factor ~6]

*Amanipour, R.M., Frisina, R.D., Cresoe, S.A., Parsons, T.J., Zhu, X., Borlongan, C.V., Walton, J.P. (2016) Impact of Mild Traumatic Brain Injury on Auditory Brain Stem Dysfunction in Mouse Model. Proc. IEEE Explore: Engineer. Med. Biol. Soc. 38,, pp. 1854-1857. doi: 10.1109/EMBC.2016.7591081.

*Amanipour, R.A., Cresoe, S., Zhu, X., Parsons, T., Borlongan, C.V., Frisina, R.D., Walton, J.P. (2016) Impact of Mild Traumatic Brain Injury on Auditory Brain Stem Dysfunction in Mouse Model. Proc. IEEE Explore: Engineer. Med. Biol. Soc. 32, 13-14.

*Halonen, J., Hinton, A., Frisina, R.D., Zhu, X., Walton, J.P. (2016) Long-term Treatment with the Mineralocorticoid Aldosterone Slows Down the Progression of Age-Related Hearing Loss Measured Behaviorally. Hearing Res. 336: 63-71. [Impact Factor ~3]

*Williamson, T.T., Zhu, X., Walton, J.P., Frisina, R.D. (2015) Auditory Brainstem Gap Responses Start to Decline in Middle Age Mice: A Novel Physiological Biomarker for Age-Related Hearing Loss. Cell & Tissue Research. 361, 359-369. [Impact Factor ~4]

Travis, L.B., Fossa, S.D., Sesso, H.D., Frisina, R.D., Herrmann, D.N., Beard, C.J., Feldman, D.R., Pagliaro, L.C., Miller, R.C., Vaughn, D.J., Einhorn, L.H., Cox, N.J., Dolan, M.E. (2014) Chemotherapy-Induced Peripheral Neuropathy and Ototoxicity: A Paradigm for Translational Genomics. J. Nat. Cancer Inst. 106(5): 1-11. [Impact Factor ~12]

Borkholder, D.A., Zhu, X., Frisina, R.D. (2014) Round Window Membrane Intracochlear Drug Delivery Enhanced by Induced Advection. J. Controlled Release. 174:171–176. [Impact Factor ~8]

*Tadros, S.F., D’Souza, M., Zhu, X., Frisina, R.D. (2014) Age-related gene expression changes for antioxidants in the CBA mouse cochlea. Plos One. 9:e90279, 1-9. [Impact Factor ~4]

*Tang, X., Zhu, X., Ding, B., Walton, J.P., Frisina, R.D., Su, J. (2014) Age-related Hearing Loss: GABA, Nicotinic acetylcholine and NMDA Receptor Expression Changes in Spiral Ganglion Neurons of the Mouse Cochlea. Neuroscience. 259, 184-193. [Impact Factor ~3]

*Ding, B., R.D. Frisina, X. Zhu, Y. Sakai, B. Sokolowski, J.P. Walton (2014) Direct control of Na+-K+-2Cl- co-transport protein (NKCC1) expression with aldosterone. Am. J. Physiol.- Cell Physiol. Endocrinol. Metabolism. 306 (1): C66-75. (PMID: 24173102) [Impact Factor ~4]

*Haghpanahia, M., Gladstone, M.B., Zhu, X., Frisina, R.D., Borkholder, D.A. (2013) Noninvasive Quantification of Transport through the Murine Cochlea Using Micro-Computed Tomography. Annals Biomedical Engineering. 41: 2130-2142. [Impact Factor ~3]

Zecker, S.G., H. Hoffman, R.D. Frisina, J. R. Dubno, S. Dhar, M. Wallhagen, Ph.D., N. Kraus, J. W. Griffith, J. P. Walton, D. A. Eddins, C. Newman, Ph.D., D. Victorson, C. M. Warrier, R. H. Wilson. (2013) Audition Assessment Using the NIH Toolbox. Neurology. 80(11 Suppl. 3):S45-48.

Newman, D.L., Fisher, L.M, Ohmen, J., Parody, R., Fong, C-T., Frisina, S.T., Mapes, F., Eddins, D.A., Frisina, D.R., Frisina, R.D., Friedman, R.A. (2012) GRM7 association with age-related hearing loss and its extension to additional features of presbycusis. Hear. Res. 294: 125-132. [Impact Factor ~3]

* Frisina, R.D., Singh, A., Bak, M., Bozorg, S., Seth, R., Zhu, X. (2011) F1 (CBA x C57) mice show superior hearing in old age relative to their parental strains: Hybrid vigor or a new animal model for "Golden Ears"? Neurobiology of Aging. 32: 1716-1724. (PMCID: PMC2891213) [Impact Factor ~6]

*Tra, Y., Frisina, R.D., D’Souza, M., (2011) A novel high-throughput analysis approach: Immune response-related genes are up-regulated in age-related hearing loss. Open Access Bioinformatics. 3: 1-16.

Margolis, R.H., Frisina, R.D., Walton, J.P. (2011) AMTAS® - Automated Method for Testing Auditory Sensitivity: III. Air Conduction Audiograms in Children and Adults. International J. of Audiology. 50: 434-439. (PMID: 21417674)

Johnson, D.G., Frisina, R.D., Borkholder, D.A. (2011) In-Plane Biocompatible Microfluidic Interconnects for Implantable Microsystems. IEEE Transactions on Biomedical Engineering. 58: 943-948. (PMID: 21147591)

Johnson, D.G., Waldron, M.J., Frisina, R.D., Borkholder, D.A. (2010) Implantable Micropump Technologies for Murine Intracochlear Infusions. IEEE Engineering in Medicine and Biology Society. 6441-6444. (PMID: 21096713; PMCID: PMC3137522)

*Charitidi, K., Frisina, R.D., Vasilyeva, O.N., Zhu, X., Canlon, B. (2010) Expression patterns of estrogen receptors in the central auditory system change in prepubertal and aged mice. Neuroscience. 170: 1270-1281. (PMID: 20736049; PMCID: PMC3133947) [Impact Factor ~3]

*Borkholder, D.A., Zhu, X., Hyatt, B.T., Archilla, A.S., Livingston, W.J., Frisina, R.D. (2010) Murine Intracochlear Drug Delivery: Reducing Concentration Gradients within the Cochlea. Hearing Res. 268: 2-11. (PMID: 20451593; PMCID: PMC2933796) [Impact Factor ~3]

Frisina, R.D., Zhu, X. (2010) Auditory sensitivity and the outer hair cell system in the CBA mouse model of age-related hearing loss. Open Access Animal Physiology. 2: 9-16. (PMCID: PMC3159169)

*Polesskaya, O., Cunningham, L.L., Francis, S.P., Luebke, A.E., Zhu, X., Collins, D., Vasilyeva, O.N., Sahler, J., Desmet, E.A., Gelbard, H.A., Maggirwara, S.B., Walton, J.P., Frisina, R.D., Dewhurst, S. (2010). Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing Res. 270, 21-27. (PMID: 20971179; PMCID: PMC2997883) [Impact Factor ~3]

*Christensen, N., D’Souza, M., Zhu, X., Frisina, R.D. (2009) Age-related hearing loss: Aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain. Brain Res. 1253: 27-34. (PMCID: PMC2670229)

*Price, K., Zhu, X., Guimaraes, P., Vasilyeva, O.N., Frisina, R.D. (2009) Hormone replacement therapy diminishes hearing in perimenopausal mice. Hearing Res. 252: 29-36. (PMCID: PMC2698030) [Impact Factor ~3]

*Vasilyeva, O.N., Frisina, S.T., Zhu, X., Walton J. P., Frisina, R.D. (2009) Interactions of hearing loss and Diabetes Mellitus in the CBA/CaJ mouse model of presbycusis. Hearing Res. 249: 44-53. (PMCID: PMC2891295) [Impact Factor ~3]

*Tadros, S.F., D’Souza, M., Zhu, X., Frisina, R.D. (2008). Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea. Apoptosis 13: 1303-1321. (PMCID: PMC2829878) [Impact Factor ~4]

*D’Souza, M., Zhu, X., Frisina, R.D. (2008) Novel Approach for Selecting Genes from RMA Normalized Microarray Data Using Functional Hearing Tests in Aging Mice. J. Neuroscience Methods, 171:279-287. (PMCID: PMC2440495)

Johnson, D.G., Zhu, X., Frisina, R.D., Borkholder, D.A. (2007) Micro-Molded Cannulae for Intracochlear Infusions in Small Rodents. 29th IEEE EMBS Annual International Conf. Proc.: Medicine & Biology, 6616-6619.

*Frisina, R.D., Newman, S.R., Zhu, X. (2007) Auditory efferent activation in CBA mice exceeds that of C57s for varying levels of noise. J. Acoustical Society of America, 121: EL-29-34.

Zettel, M.L., Zhu, X., O’Neill, W.E., Frisina, R.D. (2007) Age-related Declines in Kv 3.1b Expression in the Mouse Auditory Brainstem Correlate with Functional Deficits in the Medial Olivocochlear Efferent System. J. Assoc. Res. Otolaryngology – JARO, 8:280-293. (PMCID: PMC2538355) . [Impact Factor ~3]

*Tadros, S.F., D’Souza, M., Zettel, M.L., Zhu, X., Lynch-Erhardt, M., Frisina, R.D. (2007) Serotonin 2B Receptor: Upregulated with Age and Hearing Loss in Mouse Auditory System. Neurobiology of Aging, 28:1112-1123. [Impact Factor ~6]

*Zhu, X., Vasilyeva, O.N., Kim, S-H., Jacobson, M., Romney, J., Waterman, M.S., Tuttle, D., Frisina, R.D. (2007) Auditory efferent system declines precede age-related hearing loss: Contralateral suppression of otoacoustic emissions in mice. J. Comparative Neurology, 503: 593-604. [Impact Factor ~4]

*Tadros, S.F., D’Souza, M., Zettel, M.L., Zhu, X., Waxmonsky, N.C., Frisina, R.D. (2007) Glutamate-related gene expression in CBA mouse inferior colliculus changes with age and hearing loss. Brain Res. 1127: 1-9. (PMCID: PMC2423939)

*Kim, S-H., Frisina, R.D., Frisina, S.T., Mapes, F.M., Hickman, E.D., Frisina, D.R. (2007) Effects of Age and High-Frequency Hearing Loss on Binaural Speech Understanding using HINT. J. Acoust. Soc. (Korea). 26:1-7.

Frisina, R.D., Walton, J.P. (2006) Age-Related Structural and Functional Changes in the Cochlear Nucleus. Hearing Res. 217:216-233. [Impact Factor ~3]

*Thompson, S.K., Zhu, X., Frisina, R.D. (2006) Estrogen Blockade Reduces Auditory Feedback in CBA Mice. Otolaryngology- Head & Neck Surgery. 135:100-105.

*Kim, S-H., Frisina, R.D., Mapes, F.M., Hickman, E.D., Frisina, D.R. (2006) Effect of Age on Binaural Speech Intelligibility in Normal Hearing Adults. Speech Communication. 48:591-597.

*Frisina, S.T., Mapes, F., Kim, S-H., Frisina, D.R., Frisina, R.D. (2006) Characterization of Hearing Loss in Aged Type II Diabetics. Hearing Res. 211:103-113. (PMCID: PMC2745069) [Impact Factor ~3]

*Guimaraes, P., Frisina, S.T., Mapes, F., Tadros, S.F., Frisina, D.R., Frisina, R.D. (2006) Progestin Negatively Affects Hearing in Aged Women. Proc. National Academy Sciences - PNAS. 103: 14246-9. (PMCID: PMC1560930) [Impact Factor ~10]

RECENT BOOKS, REVIEWS, CHAPTERS, & SHORT REPORTS:
Frisina, R.D, T.T. Williamson, X. Zhu and B. Ding (In Press, 2020) The Aging Cochlea. In: Fritzsch, B., Grothe, B. Eds.; The Senses - Vol. II Audition: A Comprehensive Reference, 2nd Edition. Elsevier, Amsterdam.

Frisina, R.D, C.J. Cruz, T.T. Williamson, X. Zhu and B. Ding (In Press, 2020) Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss. In: Helfer, K., Bartlett, E.., Popper, A. & Fay, R.R. Eds.; The Aging Auditory System,. Springer Science+Business Media, LLC, New York.

Williamson, T.T. , X. Zhu, J. Pineros, B. Ding, R.D. Frisina (In Press, 2020) Understanding Hormones and Hormone Therapies’ Impacts on the Auditory System. J. Neurosci. Res.

Alex, C.S., Grinshpan, A., Bazard, P., Frisina, R.D. (In Press, 2020) A Mathematical Modeling of Infrared Neural Stimulation. Undergrad J Math Model.

Frisina, R.D. (2018) Hot Topics in Aging and Speech Communication: Current Trends and Future Directions in Basic, Clinical and Audiological Research Fields. Guest Editor, Special Issue on Aging and Speech Communication, Hear. Res. Vol. 369, pp. 1-2 (Editorial Introduction).

Frisina R.D., Budzevich M., Zhu X., Martinez G. V., Walton J.P., Borkholder D.A. (2018) Animal Model Studies Yield Translational Solutions for Cochlear Drug Delivery. Hear. Res., 368: 67-74, https://doi.org/10.1016/j.heares.2018.05.002.

Frisina, R.D. and D.R. Frisina (2017) Why Does Age-Related Hearing Loss Occur, and What Can Be Done About It? Hearing Health Fn.

Frisina, R.D. and D.R. Frisina (2016) Hormone Replacement Therapy and its Effects on Human Hearing. In: Bass, A., Sisneros, J., Popper, A. & Fay, R.R. Eds.; Hormones and Hearing. SHAR Vol. 57. Springer Science+Business Media, LLC, New York. Ch. 8, Pg. 191-209.

Frisina, R.D. and D.R. Frisina (2015) Genetics of Age-Related Hearing Loss. In: J. Miller, C. Le Prell, L. Rybak, D. Armstrong, Eds. Free Radicals in ENT Pathology: Oxidative Stress in Applied Basic Research and Clinical Practice. Switzerland: Springer-International Press, Ch. 14.

Frisina, R.D. and D.R. Frisina (2013) Physiological and Neurobiological Bases of Age-Related Hearing Loss: Biotherapeutic Implications. Am. J. Audiology. 22: 299-302.

Frisina, R.D. (2012) Hormones and Hearing: Too Much or Too Little of a Good Thing can be Ototoxic. Seminars in Hearing. 33: 231-241.

Frisina, R.D. (2010) Aging, Genetics and Central Auditory Neurobiology. Audiology Today. Sep/Oct: 53-55.

*Frisina, R.D., Zhu, X. and D’Souza, M. (2010) Biological Bases of Age-Related Hearing Loss. Hearing Care for Adults 2009 – The Challenge of Aging, Proceedings of the Phonak Second International Adult Conference. Ch. 2, pp. 19-24.

Frisina, R.D. (2010) Aging Changes in the Central Auditory System. In: Adrian Rees, Alan Palmer Eds. Handbook of Auditory Science: The Auditory Brain. Oxford: Oxford University Press, Ch. 17, pp. 415-436.

Gordon-Salant, S., Frisina, R.D., Popper, A. & Fay, R.R. (2010) The Aging Auditory System: Perceptual Characterization and Neural Bases of Presbycusis. New York: Springer-Verlag, 301 pp.

Gordon-Salant, S., Frisina, R.D. (2010) Introduction and Overview. In: Gordon-Salant, S., Frisina, R.D., Popper, A. & Fay, R.R. Eds. The Aging Auditory System: Perceptual Characterization and Neural Bases of Presbycusis. New York: Springer-Verlag, Ch. 1.

Canlon, B. & Frisina, R.D. (2009) Sex Hormones and Hearing: A Pioneering Area of Enquiry,

Co-Editors, Special Issue of Hearing Research on Sex Hormones and Hearing, Vol. 252: 1-2. (PMCID: PMC2758054)

Frisina, R.D. (2009) Age-Related Hearing Loss: Ear and Brain Mechanisms. Annals New York Academy of Sciences. 1170: 708–717.

*Vasilyeva, O.N., Frisina, S.T., Frisina, R.D. (2008) Multidisciplinary Studies Can Help Uncover Mechanisms of Age-Related Hearing Loss in Diabetics. Hearing Health, Deafness Research Foundation, Summer, pp. 43-45.

Ohlemiller, K.K. & Frisina, R.D. (2008) Clinical Characterization of Age-Related Hearing Loss and Its Neural and Molecular Bases. In: J. Schacht, A. Popper, and R.R. Fay Eds. Auditory Trauma, Protection and Treatment. New York: Springer-Verlag. Ch. 6, pp.145-194.

Frisina, R.D. (2007) Hearing and Medicine as we Age. Am. Hearing Research Fn. Newsletter, 39.

Frisina, R.D. & D.R. Frisina (2006) Methods for Studying Hearing Impairment and Auditory Problems of the Aged. In: Michael Conn. Ed. Handbook of Models for Human Aging. Amsterdam: Elsevier, Ch. 76, pp. 911-922.

Frisina, R.D. (2006) Can we Identify Genes that Contribute to Age-Related Hearing Loss? Am. Hearing Research Foundation Newsletter, 38, 4.

Frisina, R.D. (2006) Conversation – Age-related hearing loss. Long-Term Care Interface, 7, 26-27.

Frisina, R.D. & Rajan, R. (2005) Inferior Colliculus: Aging and Plasticity. In: Winer J. and Schreiner, C. Eds. The Inferior Colliculus. New York: Springer, Ch. 18, pp. 559-584.

PATENTS
United States

Forouzandeh, F., Borkholder, D.A, Frisina, R.D., Walton, J.P., Zhu, X. (2020-Pending) “Miniature Pumps”. Provisional Serial No.: 62/923,417.

Forouzandeh, F., Borkholder, D.A, Frisina, R.D., Walton, J.P., Zhu, X. (2020-Pending) “Implantable Drug Storage Devices for Drug Delivery”.

Borkholder, D.A, Forouzandeh, F., Ouyang, J., Smith, K., Carter, R., Mahajan, C., Cormier, D., Walton, J.P., Frisina, R.D. (2020-Pending) “Methods of Micropump Fabrication and Devices Thereof.”

Febles, N., Gallant, N., Ding, B., Frisina, R.D. (2020- Pending) “Otoprotective Formulations and Uses Thereof”. Provisional Serial No.: 15/894,213 .

Bazard, P., Frisina, R.D., Walton, J.P., Bhethanabotla, V.R. “Plasmonic stimulation of electrically excitable biological cells.” United States Patent No. 10,463,878B2 (Nov. 5, 2019).

Sunol, A.K., Jacobson, T., Rogers, E., Guardiano, S., Ticknor, E., Cogswell, K., Frisina, R.D., Passaglia, C. United States Patent No. 10,414,475- “Gas-Inflatable Personal Flotation Devices.” (Sept. 17, 2019).

Frisina, R.D., Walton, J.P., Ding, B., Zhu, X. “Hormone Treatment for Age-Related Hearing Loss- Presbycusis.” United States Patent No. 10,342,806 (July 9, 2019).

Bazard, P., Frisina, R.D., Walton, J.P., Bhethanabotla, V.R. “Plasmonic stimulation of electrically excitable biological cells.” United States Patent No. 9,937,359B1 (April 10, 2018).

Miller, K., Fuller, L., Taylor, J., Frisina, R.D. & Walton, J.P. “Hearing Aid with a Permanently-Adjusted Frequency Response”, United States Patent#: 5,406,633 (April, 1995).

Walton, J.P., Miller, K., Taylor, J., Fuller, L. & Frisina, R.D. “Aid to Hearing Speech in a Noisy Environment”, United States Patent#: 5,285,502 (February 1994).

International Patents
Walton, J.P., Miller, K., Taylor, J., Fuller, L., & Frisina, R.D. “Aid to Hearing Speech in a Noisy Environment”, Serial#: PCT/US 93908361.4 (1996).